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From Schedule I to the Clinic—Insights Into Psychedelic Drug Development From GHB

Brian S. Barnett, Franklin King

JAMA Psychiatry July 15, 2026 DOI: 10.1001/jamapsychiatry.2026.1901 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Review Peer reviewed
Key findings The regulatory pathway used for sodium oxybate may serve as a model for other Schedule I substances, including psychedelics.

Abstract

This Viewpoint reviews the case of sodium oxybate, a product of gamma-hydroxybutyrate (GHB), to illustrate how psychedelics and other Schedule I substances can proceed through a similar regulatory pathway.