Rethinking placebo-controlled clinical trials in psychedelic therapies for psychiatric illness.
Amy Lehrner, Thomas B Hildebrandt, Rachel Yehuda
The British Journal of Psychiatry July 21, 2025 DOI: 10.1192/bjp.2025.51 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Placebo-controlled Peer reviewed |
|---|---|
| Topics | Psychedelic-assisted therapy |
| Keywords | Methodology Placebo Psychotherapy Randomised clinical trial Psychedelic |
Abstract
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Citations in the library
Cited by 6
- Blinding Integrity in Psychedelic Randomized Clinical Trials JAMA Psychiatry April 15, 2026
- Psychedelic therapeutics in psychiatric conditions Neuropsychopharmacology January 16, 2026
- Efficacy, safety, and tolerability of lysergic acid diethylamide for the treatment of depressive symptoms: A meta-analysis and systematic review Journal of Psychopharmacology October 30, 2026
- Psychedelics in psychiatry: from promise to translation The British Journal of Psychiatry August 10, 2026
- Efficacy of 3,4-methylenedioxymethamphetamine (MDMA)-assisted therapy for posttraumatic stress disorder: A systematic review and meta-analysis of clinical and functional outcomes European Neuropsychopharmacology March 12, 2026
and 1 more in the library
Cites 5
- Blinding and expectancy confounds in psychedelic randomized controlled trials Expert Review of Clinical Pharmacology May 26, 2021
- Great Expectations: recommendations for improving the methodological rigor of psychedelic clinical trials Psychopharmacology April 1, 2022
- Expectancy Effects in Psychedelic Trials. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging May 1, 2024
- Can pragmatic research, real-world data and digital technologies aid the development of psychedelic medicine? Journal of Psychopharmacology April 22, 2021
- Control Conditions in Randomized Trials of Psychedelics The Journal of Clinical Psychiatry May 4, 2023