Toward Precision Psychedelic Therapies: Chemical, Computational, and Neuromodulatory Innovations.
Anna C. Renner, Robert B. Kargbo
ACS Medicinal Chemistry Letters October 9, 2025 DOI: 10.1021/acsmedchemlett.5c00597 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Intervention | Psilocin prodrugs |
| Topics | Psychedelic-assisted therapy |
| Key findings | Recent patents describe complementary strategies—novel psilocin prodrugs, digital cognitive state monitoring, and combining neuroplastogen drugs with transcranial electrical stimulation—that converge on a precision framework for treating neuropsychiatric disorders. |
Abstract
Recent patents disclose complementary strategies to optimize psychedelic-assisted therapy. Novel psilocin prodrugs improve pharmacokinetics and stability, while digital systems enable cognitive state monitoring during treatment. Parallel advances in combining neuroplastogen drugs with transcranial electrical stimulation highlight a model-driven approach to enhance and personalize neural plasticity. Together, these innovations converge on a precision framework for treating neuropsychiatric disorders.
Citations in the library
Cites 6
- Clinical Pharmacokinetics of Psilocin After Psilocybin Administration: A Systematic Review and Post-Hoc Analysis Clinical Pharmacokinetics 2025
- Mushrooms, Microdosing, and Mental Illness: The Effect of Psilocybin on Neurotransmitters, Neuroinflammation, and Neuroplasticity. Neuropsychiatric Disease and Treatment 2025
- Mapping psilocybin therapy: A systematic review of therapeutic frameworks, adaptations, and standardization across contemporary clinical trials Journal of Affective Disorders July 18, 2025
- Emerging mechanisms of psilocybin-induced neuroplasticity TIPS - Trends in Pharmacological Sciences September 16, 2025
- Clinical and preclinical evidence of psilocybin as antidepressant. A narrative review Progress in Neuro-Psychopharmacology and Biological Psychiatry 2025
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