Effect of ketamine enantiomers and maternal deprivation on depressive-like behavior and plasma concentration of BDNF in rats
G. Beanes, Beatriz A Carneiro, G. Marques, Pedro Guilherme B. de S. Nazaré, Israel N. Matos, G. C. D. Carvalho, C. Schitine, Alex Cleber Improta-Caria, R. S. Costa, Rejane Conceição Santana
Research, Society and Development July 15, 2024 DOI: 10.33448/rsd-v13i7.46352 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Sample size | 71 |
| Population | Male rats |
| Interventions | ketamine esketamine arketamine |
| Topics | Esketamine Ketamine |
| Key findings | Maternal deprivation did not induce depressive-like behavior, and ketamine enantiomers did not alter depressive-like behavior or plasma BDNF levels. |
Abstract
Background: Low doses of different ketamine enantiomers have demonstrated rapid behavioural and biological actions in animals with depressive-like behavior. However, some authors report different effects depending on model of depression and ketamine isomer used.
Objective: Our primary aim was to evaluate the effect of ketamine enantiomers on depressive-like behavior, anhedonic-like behavior and locomotor activity of rats subjected to maternal deprivation (MD). Secondarily, we investigated the Brain-derived neurotrophic factor plasma concentration between experimental groups.
Methods: Male rats (n=71) were randomized into seven experimental groups: one non-deprived with placebo and other six deprived split into control and intervention groups. Rats were treated with a single intraperitoneal dose of ketamine, esketamine, or arketamine. One hour after drug application, we performed experimental tests to evaluate the antidepressant-like behavior and locomotor activity. Furthermore, blood was collected to measure plasmatic BDNF levels.
Results: We did not observe induction of depressive-like in rats subjected to MD. Furthermore, there was no change in BDNF (F (6,64) = 0.9664, p=0.455) between all experimental groups.
Conclusion: Neither MD nor the different ketamine isomers were able to change depressive-like behavior or plasma BDNF levels.