Potential Pathways Involved in the Rapid Antidepressant Effects of Nitrous Oxide
Carlos A. Zarate, Rodrigo Machado‐Vieira
Biological Psychiatry July 1, 2015 DOI: 10.1016/j.biopsych.2015.04.007 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Commentary or editorial Peer reviewed |
|---|---|
| Intervention | Nitrous oxide |
| Key points | Argues that studies evaluating agents with potentially rapid antidepressant effects, such as nitrous oxide, are critical for developing new treatments and understanding the neurobiology of mood disorders. |
Abstract
Studies that evaluate agents with potentially rapid antidepres-sant effects are critical to developing new, improved treat-ments for major mood disorders. In particular, such studiesmay offer key insights into the mechanism of action of rapid-acting antidepressants as well as the neurobiology of mooddisorders (1). In their excellent article published in this issue ofBiological Psychiatry, Nagele et al. (2) investigated the anti-depressant effects of nitrous oxide (N
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- Anesthetics as Treatments for Depression: Clinical Insights and Underlying Mechanisms. Annual Review of Neuroscience February 19, 2025
- Rapid antidepressant potential of nitrous oxide: current state and major questions. Molecular Psychiatry June 1, 2026
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Cites 3
- Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial. Biological Psychiatry July 1, 2015
- Humphry Davy, nitrous oxide, the Pneumatic Institution, and the Royal Institution. American Journal of Physiology - Lung cellular and Molecular Physiology November 1, 2014
- Ketamine and the next generation of antidepressants with a rapid onset of action Pharmacology & Therapeutics May 3, 2009