Evaluation of Histopathologic Findings and Safety of Intravitreal Ketamine Administration on Vitreoretinal Tissue in Rat Model: A Pilot Study.
Mehdi Sanatkar, Zohreh Nozarian, Parisa Abdi, Fatemeh Bazvand
Journal of current ophthalmology 2023 DOI: 10.4103/joco.joco_230_23 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Controlled preclinical study Pilot study Peer reviewed |
|---|---|
| Sample size | 10 |
| Population | Rats |
| Intervention | Intravitreal injection of ketamine |
| Dose | 0.1 ml of ketamine 0.01 mol/L |
| Duration | 1-month follow-up |
| Topics | Ketamine Esketamine |
| Keywords | Intravitreal Rat Ophthalmology Drug-safety Anesthetics Preclinical-research Ocular-medicine |
| Key points | Intravitreal injection of ketamine at 0.01 mol/L caused no adverse histological effects on intraocular tissues in rats. |
Abstract
To evaluate the safety and histological findings of intravitreal injection of ketamine in rats. Each rat received a total volume of 0.1 ml of ketamine 0.01 mol/L (5 rats as ketamine group) or a total of 0.1 ml of normal saline 0.9% (5 rats as control group) under general anesthesia in a sterile condition. A histology assessment was performed 1 month after the intravitreal injection. Lens opacity, necrosis, and atrophy of retinal layers and optic disc were not seen in five specimens in the ketamine group and five in the normal saline group. There was no inflammation in the vitreous, retinal layers, choroid, optic disc, and optic nerve in both groups. Intravitreal injection of ketamine in a special dose has no obvious adverse effect on diverse intraocular tissue.
Comparable studies
Other preclinical and animal studies on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists Rats | 2010 | Observational study | |
| Activation of Glutamatergic Neurotransmission by Ketamine: A Novel Step in the Pathway from NMDA Receptor Blockade to Dopaminergic and Cognitive Disruptions Associated with the Prefrontal Cortex Conscious rats | 1997 | Dose-response study with microdialysis and behavioral testing | |
| NMDAR inhibition-independent antidepressant actions of ketamine metabolites Mice | 2016 | Preclinical study | |
| The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N‐methyl‐aspartate Spinal neurons in decerebrate or pentobarbitone-anaesthetized cats and rats | 1983 | Experimental study | |
| R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects Mice | 2015 | Experimental study |
Citations in the library
Cites 2
- Neuroprotective effects of curcumin-loaded nanophytosome on ketamine-induced schizophrenia-like behaviors and oxidative damage in male mice. Neuroscience Letters September 15, 2021
- Ketamine-induced antidepressant like effects in mice: A possible involvement of cannabinoid system. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie April 1, 2019