Exploring the impact of music on response to ketamine/esketamine: A scoping review.
Mina Kheirkhah, Allison C. Nugent, Alicia A Livinski, Lucinda Neely, Sara C Johnson, Ioline D. Henter, Shahaboddin Dabaghi Varnosfaderani, Rebecca B Price, Nadia S. Hejazi, Mani Yavi, Hamidreza Jamalabadi, Nooshin Javaheripour, Martin Walter, Carlos A. Zarate
Neuroscience and Biobehavioral Reviews July 1, 2024 DOI: 10.1016/j.neubiorev.2024.105693 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Scoping review Peer reviewed |
|---|---|
| Topics | Esketamine Ketamine |
| Keywords | Anesthesia Ketamine-assisted therapy Music intervention Music healing Psychedelic-assisted treatment |
| Citations | 13 |
| Key findings | This scoping review is the first comprehensive exploration of the interplay between music and ketamine/esketamine in humans, describing existing studies across diverse populations and treatment contexts. |
Abstract
Music and ketamine are both known to affect therapeutic outcomes, but few studies have investigated their co-administration. This scoping review describes the existing literature on the joint use of music and ketamine-or esketamine (the S(+) enantiomer of ketamine)-in humans. The review considers that extant studies have explored the intersection of ketamine/esketamine and music in healthy volunteers and in patients of various age groups, at different dosages, through different treatment processes, and have varied the sequence of playing music relative to ketamine/esketamine administration. Studies investigating the use of music during ketamine anesthesia are also included in the review because anesthesia and sedation were the early drivers of ketamine use. Studies pertaining to recreational ketamine use were omitted. The review was limited to articles published in the English language but not restricted by publication year. To the best of our knowledge, this scoping review is the first comprehensive exploration of the interplay between music and ketamine/esketamine and offers valuable insights to researchers interested in designing future studies.