Cannabis consumption and psychosis or schizophrenia development
M. B. Ortiz-Medina, M. Perea, Julio Torales, Antonio Ventriglio, G. Vitrani, L. Aguilar, C. Roncero
International Journal of Social Psychiatry November 1, 2018 DOI: 10.1177/0020764018801690 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review Peer reviewed |
|---|---|
| Population | Humans without schizophrenia |
| Topics | Cannabis |
| Key findings | Cannabis use doubles the risk of developing psychosis in vulnerable people, with dose and age of first use influencing the association. |
Abstract
Objective: Cannabis consumption produces psychopathology, in some cases psychotic episodes, which are of our interest in this work. However, the relationship between cannabis use and psychosis has not been fully elucidated. The objectives of this work are to (1) review the current state of knowledge on the association of cannabis use with the risk of the development of psychosis or psychotic symptoms in people without schizophrenia and (2) assess the consistency of the hypothesis that cannabis use is associated with increased risk of psychosis in people without schizophrenia.
Method: This work included research done in humans until May 2018 with the keywords ‘cannabis’ and ‘psychosis’, published in English and Spanish, in the PubMed database.
Results: In all, 66 papers were analyzed, of which 23 were cohort trials and 43 were reviews.
Conclusion: Cannabis use doubles the risk of developing psychosis in vulnerable people. There even exists a relationship regarding the dose used and the age of first use. Gene–environment interactions that modulate the association between cannabis use and the presence of psychosis have also been described.
Comparable studies
Other systematic reviews and meta-analyses on cannabis, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Effects of cannabis use on outcomes of psychotic disorders: systematic review People with psychotic disorders, as examined in 13 longitudinal studies | 2008 | Systematic review | |
| The Impact of Cannabis Use on Cognitive Functioning in Patients With Schizophrenia: A Meta-analysis of Existing Findings and New Data in a First-Episode Sample Patients with established schizophrenia (meta-analysis: 572) and patients with... | 2010 | Meta-analysis and cross-sectional observational study | n = 700 |
| Medicinal cannabis for psychiatric disorders: a clinically-focused systematic review | 2020 | Systematic review | |
| Neuroimaging in cannabis use: a systematic review of the literature Cannabis users and controls in neuroimaging studies | 2009 | Systematic review | |
| Human Laboratory Studies on Cannabinoids and Psychosis. Healthy human subjects and individuals with schizophrenia | 2016 | Systematic review |
Citations in the library
Cited by 16
- Duration of Untreated Disorder and Cannabis Use: An Observational Study on a Cohort of Young Italian Patients Experiencing Psychotic Experiences and Dissociative Symptoms International Journal of Environmental Research and Public Health November 30, 2021
- Association between cannabis use and symptom dimensions in schizophrenia spectrum disorders: an individual participant data meta-analysis on 3053 individuals EClinicalMedicine September 8, 2023
- Association between formal thought disorder and cannabis use: a systematic review and meta-analysis Schizophrenia September 29, 2022
- A Case Report of Psilocybin-induced Psychosis in a Predisposed Patient Clinical Psychopharmacology and Neuroscience May 21, 2024
- Cannabis and Psychosis: A Review of the Risk Factors Involved American Journal of Plant Sciences 2020
and 11 more in the library
Cites 19
- Causal association between cannabis and psychosis: examination of the evidence The British Journal of Psychiatry January 30, 2004
- Psychiatric effects of cannabis The British Journal of Psychiatry February 1, 2001
- Continued cannabis use and risk of incidence and persistence of psychotic symptoms: 10 year follow-up cohort study BMJ March 1, 2011
- Effects of cannabis use on outcomes of psychotic disorders: systematic review The British Journal of Psychiatry October 31, 2008
- Cannabis use and psychotic disorders: an update Drug and Alcohol Review November 30, 2004
and 14 more in the library