Genotoxic and mutagenic evaluation of Ayahuasca in peripheral blood and bone marrow of Mus musculus.
Patrícia Hermínio Cunha Feitosa, Melquisedeque da Rocha Viana, José Figueredo‐Silva, Danniel Cabral Leão Ferreira, Maria de Oliveira, A. G. de Oliveira, Lucas Rodrigo Batista Leite, Mônica C. Santos, Maria Silva, Maurício Do Amaral, Fabrício Do Amaral
January 30, 2024 DOI: 10.22541/au.170665785.51975039/v1 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | In vivo experimental study |
|---|---|
| Population | Mus musculus (mice) |
| Intervention | Ayahuasca (Santo Daime or Daime tea) |
| Topics | Ayahuasca |
| Keywords | Genotoxicity Micronucleus test Context archaeology Bone marrow Comet assay Pharmacology Traditional medicine Toxicology Dna damage Genetics Immunology Ecology |
| Key findings | Ayahuasca did not induce genotoxic or mutagenic effects in mice as measured by the COMET assay and micronucleus test. |
Abstract
Ayahuasca (Santo Daime or Daime tea) is the Quechua name for a tea obtained from the Banisteriopsis caapi vine ( B. caapi ) with the leaves of the Psychotria viridis ( P.viridis ) shrub. For generations, this beverage has been used in spiritual rituals by indigenous communities in the Amazon. Its promising neuropharmacological properties and its use as an alternative therapy in medical procedures has generated discussions about its safety. In this context, more experimental investigations must be encouraged so that the scientific data generated can contribute to its more correct use. For this work, we conducted an in vivo investigation of the possible genotoxic and mutagenic effects of ayahuasca. We used peripheral blood (COMET assay) and bone marrow (MN micronucleus test) from Mus musculus after oral administration of the tea. The results did not indicate genotoxic effects for the COM assay (tail length and percentage of DNA) when compared to the negative control, nor mutagenic effects for the MN test. Therefore, we found no evidence of genotoxicity or mutagenicity that reinforces the discussion about the harmful effects of this beverage.
Comparable studies
Other preclinical and animal studies on ayahuasca, most cited first.
Citations in the library
Cites 8
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and 3 more in the library