Automated Detection of Psychedelic-Induced Head-Twitch Response in Mice
Alaina M Jaster, Javier González-Maeso
Schizophrenia 2023 DOI: 10.1007/978-1-0716-3307-6_6 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Methodological description Peer reviewed |
|---|---|
| Population | Mice |
| Interventions | 1-(2 5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) |
| Keywords | Head-twitch response htr Behavioral model Psychosis Psychedelics Hallucinogen Schizophrenia Rodent models Preclinical |
| Key points | A magnetic ear tag reporter with automated quantification and biphasic detection can identify head-twitch response in mice treated with DOI. |
Abstract
Head-twitch response (HTR) allows for the detection and classification of behavior associated with serotonin 2A receptor (5-HT_2AR) activation upon psychedelic administration in rodent models. This activation and functional output can be utilized to provide insights into molecular mechanisms associated with psychosis and to identify signaling processes related to existing and novel antipsychotic and psychedelic compounds. Here we describe the use of a magnetic ear tag reporter coupled with automated quantification and biphasic detection to identify HTR in mice treated with the classical psychedelic 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI).
Citations in the library
Cited by 3
- 1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI): From an Obscure to Pivotal Member of the DOX Family of Serotonergic Psychedelic Agents - A Review. ACS Pharmacology & Translational Science June 14, 2024
- High dose of psilocybin induces acute behavioral changes without inducing conditioned place preference in Sprague-Dawley rats Journal of Psychopharmacology September 22, 2025
- Rapid, open-source, and automated quantification of the head twitch response in C57BL/6J mice using DeepLabCut and Simple Behavioral Analysis bioRxiv Preprint Server April 28, 2025
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