The Psychotherapy in MDMA-Assisted Psychotherapy
Ioana Alina Cristea, Pim Cuijpers, Joar Øveraas Halvorsen
JAMA Psychiatry November 1, 2024 DOI: 10.1001/jamapsychiatry.2024.2887 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Intervention | MDMA-assisted psychotherapy |
| Topics | MDMA Psychedelic-assisted therapy |
| Key points | Argues that the psychotherapy component in MDMA-assisted psychotherapy trials for PTSD is a critical but overlooked factor in assessing trial validity. |
Abstract
This Viewpoint discusses the critical yet overlooked role of the psychotherapy component in assessing the validity of the trials of midomafetamine/3,4-methylenedioxymethamphetamine (MDMA)–assisted psychotherapy for posttraumatic stress disorder.
Comparable studies
Other theoretical and historical papers on MDMA and psychedelic-assisted therapy, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The potential use of N-methyl-3,4-methylenedioxyamphetamine (MDMA) assisted psychotherapy in the treatment of eating disorders comorbid with PTSD. | 2021 | Theoretical or philosophical paper | |
| MDMA-assisted psychotherapy for PTSD in adolescents: rationale, potential, risks, and considerations. Adolescents with PTSD | 2024 | Theoretical or philosophical paper | |
| Couple Therapy With MDMA-Proposed Pathways of Action. | 2021 | Theoretical or philosophical paper | |
| Informed Consent in Psychedelic-Assisted Therapy. | 2024 | Theoretical or philosophical paper | |
| The “Third” Eye: Ethics of Video Recording in the Context of Psychedelic-Assisted Therapy | 2023 | Theoretical or philosophical paper |
Citations in the library
Cited by 16
- An Update on Psychotherapy for the Treatment of PTSD. American Journal of Psychiatry May 1, 2025
- Key competencies for psychedelic treatment in real-world mental health care settings. General Hospital Psychiatry 2025
- Psychedelic-assisted therapy as a complex intervention: implications for clinical trial design Therapeutic Advances in Psychopharmacology September 1, 2025
- MDMA-Assisted Therapy for Post-Traumatic Stress Disorder: Regulatory Challenges and a Path Forward. CNS Drugs April 1, 2025
- Reframing psychedelic regulation: Tools, not treatments Drug Science, Policy and Law June 16, 2025
and 11 more in the library
Cites 4
- MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study. Nature Medicine June 1, 2021
- MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial. Nature Medicine October 1, 2023
- Expectancy Effects Cannot Be Neglected in MDMA-Assisted Therapy Research. ACS Chemical Neuroscience November 15, 2023
- A Novel, Brief, Fully Automated Intervention to Extend the Antidepressant Effect of a Single Ketamine Infusion: A Randomized Clinical Trial American Journal of Psychiatry September 21, 2022