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Ketamine-Assisted Psychodynamic Psychotherapy.

John G Cottone

Psychodynamic psychiatry December 1, 2023 DOI: 10.1521/pdps.2023.51.4.467 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Case report Peer reviewed
Sample size 1
Population 54-year-old woman with multiple traumas, sexual assault, life-threatening physical injuries, and primary lateral sclerosis (PLS)
Intervention Ketamine-assisted psychotherapy (KAP)
Topics Psychedelic-assisted therapy Esketamine Ketamine
Keywords Ketamine-assisted psychotherapy Psychodynamic psychotherapy
Key findings After a KAP session, the patient discovered unconscious idealizing tendencies and secondary gain from physical symptoms, leading to reduced idealization and fewer symptom exacerbations.

Abstract

This case report details the treatment of a longtime psychodynamic psychotherapy patient, with a particular focus on a ketamine-assisted psychotherapy (KAP) session, and how the progress achieved during this session compares with the literature on KAP. The patient is a 54-year-old woman with a history of multiple traumas, including sexual assault and life-threatening physical injuries, as well as a recent diagnosis of primary lateral sclerosis (PLS). For most of her life, she relied on extreme idealization of important people in her life as her primary defense mechanism, helping her to maintain physical and psychological survival. However, after a KAP session in January 2023 she discovered the consequences of her extreme idealizing tendencies. Among these was the creation of troubling double binds for the people she idealized, as well as the fomentation of conflict between these individuals with each other. Also unconscious was the secondary gain offered by her escalating physical symptoms and pain-that is, the ability to resolve conflicts between those she idealized-and how this secondary gain increased the likelihood of symptom exacerbations during periods of conflict. After the discovery of these unconscious tendencies during her KAP session, the patient has since been able to avoid extreme idealization of important people in her life and has subsequently experienced fewer episodes of exacerbation of her physical symptoms. Consistent with the opinions of clinicians and researchers published in the literature, the achievement of a psychedelic trance state appeared necessary for the success of the patient's KAP treatment.

Comparable studies

Other case reports and case series on ketamine and psychedelic-assisted therapy, most cited first.

Study Year Design Participants
Ketamine-assisted psychotherapy in adolescents with multiple psychiatric diagnoses. Adolescents aged 14–19 with comorbid psychiatric diagnoses including... 2023 Case series n = 4
Case report: Adult with bipolar disorder and autism treated with ketamine assisted psychotherapy. A 29-year-old man with bipolar disorder, Autism Spectrum Disorder, and type 2 diabetes 2024 Case study n = 1
Reconnecting through dissociation: a 5-month follow-up case study on ketamine-assisted psychotherapy for anorexia nervosa. Female patient in her late twenties with anorexia nervosa and comorbid depression 2025 Case report n = 1
Ketamine-Assisted Psychotherapy for Treatment of Co-occurring Borderline Personality Disorder and Depression: A Case Study. A patient with co-occurring borderline personality disorder and depression 2025 Case study n = 1
Qualitative analysis of a patient's experience of ketamine-assisted psychotherapy for substance use disorder: Empirical synergies with twelve-step programs 28-year-old female treated for alcohol and opioid use disorder 2025 Case study n = 1

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