Ketamine in Bipolar Disorder: A Review
Alina Wilkowska, Łukasz P. Szałach, Wiesław Jerzy Cubała
Neuropsychiatric Disease and Treatment November 1, 2020 DOI: 10.2147/ndt.s282208 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | Depression Ketamine Esketamine |
| Keywords | Bipolar disorder Depression economics Suicide rates Lithium medication Poison control Cognition Suicide prevention Medical emergency |
| Citations | 31 |
| Key points | Argues that ketamine might be a promising treatment for bipolar disorder due to its rapid antidepressive and antisuicidal effects. |
Abstract
Abstract: Bipolar disorder (BD) is a psychiatric illness associated with high morbidity, mortality and suicide rate. It has neuroprogressive course and a high rate of treatment resistance. Hence, there is an unquestionable need for new BD treatment strategies. Ketamine appears to have rapid antidepressive and antisuicidal effects. Since most of the available studies concern unipolar depression, here we present a novel insight arguing that ketamine might be a promising treatment for bipolar disorder. Keywords: ketamine, bipolar disorder, staging, neuroprogression, treatment resistance
Comparable studies
Other theoretical and historical papers on ketamine for depression, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| An Integrative Approach to Ketamine Therapy May Enhance Multiple Dimensions of Efficacy: Improving Therapeutic Outcomes With Treatment Resistant Depression. | 2021 | Theoretical or philosophical paper | |
| Arketamine for cognitive impairment in psychiatric disorders | 2023 | Theoretical or philosophical paper | |
| The Montreal model: an integrative biomedical-psychedelic approach to ketamine for severe treatment-resistant depression | 2023 | Theoretical or philosophical paper | |
| Rethinking the role of TRKB in the action of antidepressants and psychedelics. | 2024 | Theoretical or philosophical paper | |
| Off-label use of ketamine for treatment-resistant depression in clinical practice: European perspective. | 2019 | Theoretical or philosophical paper |