Ketamine as a Treatment Option for Severe Borderline Personality Disorder
Helena Rogg, Mihai Avram, Felix Müller, Klaus Junghanns, Stefan Borgwardt, Bartosz Zurowski
Journal of Clinical Psychopharmacology December 30, 2022 DOI: 10.1097/jcp.0000000000001642 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Intervention | Ketamine |
| Topics | Ketamine Esketamine |
| Keywords | Borderline personality disorder Psychoanalysis Psychotherapist |
| Citations | 8 |
| Key findings | Ketamine may reduce symptom severity in borderline personality disorder, but evidence is preliminary and limited. |
Abstract
Rogg, Helena MD; Avram, Mihai PhD; Müller, Felix MD; Junghanns, Klaus MD; Borgwardt, Stefan MD; Zurowski, Bartosz MD Author Information
Comparable studies
Other narrative reviews on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms | 2018 | Review | |
| Mechanisms of Ketamine Action as an Antidepressant | 2018 | Review | |
| Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation Adults with treatment-resistant depression | 2021 | Review | |
| Ketamine Pharmacology: An Update (Pharmacodynamics and Molecular Aspects, Recent Findings) | 2013 | Review | |
| A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders | 2017 | Review and consensus statement |
Citations in the library
Cited by 6
- Depression with comorbid borderline personality disorder - could ketamine be a treatment catalyst? Frontiers in Psychiatry 2024
- Very Low-Dose Sublingual Ketamine for Borderline Personality Disorder and Treatment-Resistant Depression. Cureus April 1, 2024
- Ketamine/esketamine in the treatment of depression with comorbid borderline personality disorder or traits: A systematic review of effectiveness Australian & New Zealand Journal of Psychiatry September 20, 2025
- Ketamine-Assisted Psychotherapy for Antisocial Personality Disorder: A Case Report. Journal of Psychoactive Drugs January 7, 2025
- Psychedelics as a potential treatment for borderline personality disorder: A narrative review. Psychiatry Research July 1, 2026
and 1 more in the library
Cites 7
- The effect of a single dose of intravenous ketamine on suicidal ideation: a systematic review and individual participant data meta-analysis American Journal of Psychiatry October 3, 2017
- Ketamine for rapid reduction of suicidal thoughts in major depression: a midazolam-controlled randomized clinical trial American Journal of Psychiatry December 5, 2017
- Ketamine for rapid reduction of suicidal ideation: a randomized controlled trial Psychological Medicine August 12, 2015
- Ketamine for the treatment of mental health and substance use disorders: comprehensive systematic review BJPsych Open December 23, 2021
- “Esketamine” in Borderline Personality Disorder: A Look Beyond Suicidality Cureus April 30, 2022
and 2 more in the library