Possible Interactions Between 5-HT2A Receptors and the Endocannabinoid System in Humans
Rafael G. Dos Santos, José Alexandre S. Crippa, Flávia de Lima Osório, Juliana Mendes Rocha, Giordano Novak Rossi, Camila Marchioni, Maria Eugênia Costa Queiroz, Gabriela de Oliveira Silveira, Maurı́cio Yonamine, Jaime E. C. Hallak
Journal of Clinical Psychopharmacology October 19, 2018 DOI: 10.1097/jcp.0000000000000973 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Peer reviewed |
|---|---|
| Sample size | 29 |
| Population | Volunteers with social anxiety disorder |
| Duration | Single dose, with follow-up over several days |
| Measures | HAM-D |
| Topics | Serotonin |
| Keywords | Endocannabinoid system Receptor |
| Citations | 9 |
| Key findings | A single dose of ayahuasca reduced anxiety symptoms in individuals with social anxiety disorder compared to placebo. |
Abstract
dos Santos, Rafael Guimarães PhD; Crippa, José Alexandre MD, PhD; Osório, Flávia de Lima PhD; Rocha, Juliana M. BSc; Rossi, Giordano Novak BSc; Marchioni, Camila BSc; Queiroz, Maria Eugênia Costa PhD; Silveira, Gabriela O. BSc; Yonamine, Mauricio PhD; Hallak, Jaime Eduardo Cecilio MD, PhD Author Information
Comparable studies
Other randomized controlled trials on serotonin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose?effect study Healthy human subjects | 2004 | Randomized controlled trial | n = 8 |
| Dose-Response Study of N,N-Dimethyltryptamine in Humans Experienced hallucinogen users | 1994 | Double-blind, saline placebo-controlled, randomized study | n = 12 |
| Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects Healthy subjects (8 women, 8 men) | 2014 | Double-blind, randomized, placebo-controlled, crossover study | n = 16 |
| Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor Healthy human participants | 2018 | Double-blind, randomized, counterbalanced, cross-over study | n = 24 |
| Activation of Serotonin 2A Receptors Underlies the Psilocybin-Induced Effects on Oscillations, N170 Visual-Evoked Potentials, and Visual Hallucinations Healthy human subjects | 2013 | Randomized controlled trial |
Citations in the library
Cited by 8
- Ayahuasca, an ancient substance with traditional and contemporary use in neuropsychiatry and neuroscience Epilepsy & Behavior June 7, 2019
- Effects of repeated lysergic acid diethylamide (LSD) on the mouse brain endocannabinoidome and gut microbiome. British Journal of Pharmacology March 1, 2023
- Molecular Pathways of the Therapeutic Effects of Ayahuasca, a Botanical Psychedelic and Potential Rapid-Acting Antidepressant Biomolecules November 2, 2022
- How does ayahuasca work from a psychiatric perspective? Pros and cons of the entheogenic therapy. Human Psychopharmacology: Clinical and Experimental May 1, 2020
- Effects of ayahuasca on the endocannabinoid system of healthy volunteers and in volunteers with social anxiety disorder: Results from two pilot, proof‐of‐concept, randomized, placebo‐controlled trials Human Psychopharmacology: Clinical and Experimental February 2, 2022
and 3 more in the library
Cites 6
- Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial Psychological Medicine June 15, 2018
- Antidepressant Effects of a Single Dose of Ayahuasca in Patients With Recurrent Depression Journal of Clinical Psychopharmacology December 11, 2015
- Human Pharmacology of Ayahuasca: Subjective and Cardiovascular Effects, Monoamine Metabolite Excretion, and Pharmacokinetics Journal of Pharmacology and Experimental Therapeutics June 18, 2003
- Effects of ayahuasca on psychometric measures of anxiety, panic-like and hopelessness in Santo Daime members Journal of Ethnopharmacology April 26, 2007
- Cortisol Modulation by Ayahuasca in Patients With Treatment Resistant Depression and Healthy Controls Frontiers in Psychiatry May 8, 2018
and 1 more in the library