Effects of Different Anesthesia Applications on Mood, Depression, and Anxiety Levels in Burn Patients.
Ayça Tuba Dumanlı Özcan, Betül Akaycan, Serdar Süleyman Can, Özlem Karakaya, Emine Sönmez, Ahmet Çınar Yastı, Orhan Kanbak
Journal of Burn Care & Research November 14, 2024 DOI: 10.1093/jbcr/irae105 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Sample size | 67 |
| Population | Patients with burns aged 18-65 years, ASA I-II class, with basic communication skills and no history of diagnosed mental illness or neuropsychiatric disorders |
| Interventions | Ketamine sedation General anesthesia |
| Dose | 1 mg/kg IV ketamine |
| Duration | Postoperative day 1 |
| Topics | Depression Ketamine Anxiety |
| Keywords | Patients with burns Suicidal tendencies Mental health Burn treatment Ketamine therapy Psychiatric medicine Pain management |
| Citations | 4 |
| Key findings | Ketamine sedation significantly reduced postoperative depression scores in burn patients compared to their preoperative scores, and no patient showed suicidal ideation. |
Abstract
Adequate and effective pain management and prevention of depression are essential in patients with burns. This study aims to explore the effects of ketamine sedation in patients with burns in terms of mood disorders, depression, anxiety, and suicidality during postoperative follow-up in the intensive care unit. This study targeted subjects aged 18-65 years, in the ASA I-II class, with basic communication skills, no history of diagnosed mental illness, and no history of neuropsychiatric or cognitive disorders or related treatment. The study was conducted on 67 patients. After preoxygenation, anesthesia induction was practiced with 2 mg/kg intravenous (IV) propofol and 1 mcg/kg IV fentanyl in the general anesthesia group. Anesthesia was continued with a mixture of 0.3-0.5 mcg/kg/min remifentanil, 2% sevoflurane, 50% air, and 50% oxygen. In the sedation group, 1 mcg/kg IV fentanyl and 1 mg/kg IV ketamine were administered at induction; anesthesia was maintained by adding 30-50 mg IV propofol if necessary. The Montgomery-Asberg Depression Rating Scale (MADRS), Hamilton Anxiety Rating Scale (HAM-A), and Beck Scale for Suicidal Ideation (BSSI) have been administered via way of means of a psychiatrist preoperatively and on the primary postoperative day. In intragroup evaluations, MADRS values for the sedation anesthesia group decreased statistically significantly after the anesthesia (11.63 ± 5.49) compared to the preanesthesia period (14.44 ± 7.22) (P < .001). HAM-A scores of both anesthesia groups decreased statistically significantly after anesthesia. No patient was found to have suicidal ideation in all evaluations in which BSSI was used. Patients with burns may have a high potential for depression, anxiety disorders, and suicidal tendencies due to the trauma they have experienced. In these patients, sedation anesthesia with ketamine may reduce negative mood, depression, anxiety, and suicidal tendencies in the postoperative period.
Comparable studies
Other observational and cohort studies on ketamine for anxiety, most cited first.
Citations in the library
Cites 5
- Mechanisms of Ketamine Action as an Antidepressant Molecular Psychiatry March 13, 2018
- Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression JAMA Psychiatry December 27, 2017
- Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial. American Journal of Psychiatry March 29, 2019
- Retrospective data analysis to determine the effectiveness of intravenous ketamine therapy on patients suffering from depression with suicidal ideation Industrial Psychiatry Journal 2023
- Ketamine for Treatment of Posttraumatic Stress Disorder: State of the Field. FOCUS: The Journal of Lifelong Learning in Psychiatry July 2023