Cellular and Biochemical Alterations Induced in Vitro by Δ^1-Tetrahydrocannabinol: Effects on Cell Proliferation, Nucleic Acids, Plasma Cell Membrane ATPase, and Adenylate Cyclase
Jacques Huot
Marihuana 1976 DOI: 10.1007/978-3-642-51624-5_27 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | In vitro study Peer reviewed |
|---|---|
| Population | Cells cultivated in vitro |
| Topics | Cannabis |
| Keywords | Atpase activity Neuroblastoma cell Adenylate cyclase activity Adenosine triphosphatase |
| Citations | 6 |
| Key points | THC induces cellular and biochemical alterations in cultured cells, but these in vitro findings should not be hastily extrapolated to humans. |
Abstract
The psychodysleptic effect produced by Δ^1-tetrahydrocannabinol (Δ^1-THC) is well known and was described in detail by Moreau [20] in 1845. However, the basic cellular mechanisms which underlie the development of the psychodysleptic syndrome still are not very clear. This present work describes some cellular and biochemical alterations induced by THC in cells cultivated in vitro , an experimental model which offers many advantages in the investigation of the mechanism of action of a drug on the cell. However, the results of such in vitro studies should not be extrapolated hastily to interpret the action of these drugs in man.
Comparable studies
Other preclinical and animal studies on cannabis, most cited first.