Controversies of the Effect of Ketamine on Cognition
Frontiers in Psychiatry March 29, 2016 DOI: 10.3389/fpsyt.2016.00047 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Intervention | Ketamine |
| Topics | Esketamine Ketamine |
| Citations | 39 |
| Key findings | The authors report that published literature generally describes ketamine as an effective rapid antidepressant, with intravenous ketamine reducing suicidal ideation by 29% to 79% across studies. They note that this rapid antidepressant effect is transient, and that researchers have recommended continued long-term administration. |
Abstract
Over the last couple of years, there have been numerous studies investigating the efficacy of ketamine, a non-competitive N-methyl-d-aspartic acid (NMDA) receptor antagonist as a rapid antidepressant. Most of the existing published literature describes the purported effectiveness of ketamine as a rapid antidepressant. The clinical efficacy of intravenous ketamine in the reduction of suicidal ideations ranged between that of 29% to as much as 79%. Researchers have noted the transient nature of intravenous ketamine’s rapid antidepressant efficacy and hence has recommended for long-term continued administration (1, 2).
Comparable studies
Other narrative reviews on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms | 2018 | Review | |
| Mechanisms of Ketamine Action as an Antidepressant | 2018 | Review | |
| Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation Adults with treatment-resistant depression | 2021 | Review | |
| Ketamine Pharmacology: An Update (Pharmacodynamics and Molecular Aspects, Recent Findings) | 2013 | Review | |
| A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders | 2017 | Review and consensus statement |
Citations in the library
Cited by 16
- Ketamine as an antidepressant: overview of its mechanisms of action and potential predictive biomarkers Therapeutic Advances in Psychopharmacology 2020
- Predictors of Response to Ketamine in Treatment Resistant Major Depressive Disorder and Bipolar Disorder International Journal of Environmental Research and Public Health April 17, 2018
- Oral ketamine for depression: An updated systematic review The World Journal of Biological Psychiatry January 18, 2023
- Harm related to recreational ketamine use and its relevance for the clinical use of ketamine. A systematic review and comparison study Expert Opinion on Drug Safety June 26, 2021
- The Possible Application of Ketamine in the Treatment of Depression in Alzheimer’s Disease Neurology International June 23, 2022
and 11 more in the library