Change in patient‐centered outcomes of psychological well‐being, sleep, and suicidality following treatment with intravenous ketamine for late‐life treatment‐resistant depression
Benjamin Vanderschelden, M. A. Gebara, H. Oughli, M. Butters, Patrick J. Brown, Nuri B Farber, A. Flint, J. Karp, Helen Lavretsky, Benoit H. Mulsant, C. Reynolds, S. Roose, Eric J Lenze
International Journal of Geriatric Psychiatry July 1, 2023 DOI: 10.1002/gps.5964 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Older adults with late-life treatment-resistant depression |
| Intervention | Intravenous ketamine |
| Topics | Depression Esketamine Ketamine |
| Citations | 13 |
| Key findings | Intravenous ketamine improved psychological well-being and sleep but did not improve suicidality in older adults with treatment-resistant depression. |
Abstract
To examine whether psychological well‐being, sleep, and suicidality improved with treatment with intravenous (IV) ketamine for late‐life treatment‐resistant depression (TRD).
Comparable studies
Other observational and cohort studies on ketamine for depression, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Concomitant BDNF and sleep slow wave changes indicate ketamine-induced plasticity in major depressive disorder Patients with treatment-resistant major depressive disorder | 2012 | Observational cohort | n = 30 |
| Altered peripheral immune profiles in treatment-resistant depression: response to ketamine and prediction of treatment outcome Healthy controls and actively depressed patients with treatment-resistant depression... | 2017 | Observational cohort | n = 59 |
| Clinical Predictors of Ketamine Response in Treatment-Resistant Major Depression Treatment-resistant inpatients with DSM-IV-TR-diagnosed major depressive disorder or... | 2014 | Post hoc analysis of pooled data from four studies | n = 108 |
| An investigation of amino-acid neurotransmitters as potential predictors of clinical improvement to ketamine in depression Drug-free patients with major depressive disorder | 2011 | Observational cohort | n = 14 |
| Efficacy of ketamine therapy in the treatment of depression Drug-free/naïve men with severe depression, no history of psychotic disorder, head... | 2019 | Observational cohort | n = 25 |
Citations in the library
Cited by 6
- Patient-reported outcomes on sleep quality and circadian rhythm during treatment with intravenous ketamine for treatment-resistant depression. Therapeutic Advances in Psychopharmacology 2024
- Effects of ketamine on sleep and circadian rhythmicity in major depressive disorder and bipolar disorder: A systematic review. Journal of Affective Disorders May 6, 2026
- Self-Reported Improvements in Comorbid Post-Traumatic Stress Disorder Symptoms, Depression, Anxiety, and Sleep Among Real-World Patients Receiving Medical Ketamine: Exploring the Role of Adjunct Therapies. European Journal of Trauma & Dissociation September 1, 2025
- Symptom trajectories and clinical outcomes of intravenous ketamine in treatment-resistant depression: A real-world study using group-based trajectory modeling. Journal of Affective Disorders January 23, 2026
- The effect of glutamatergic modulators on sleep behavior and architecture in depressive disorders: A systematic review. Journal of Psychiatric Research June 1, 2026
and 1 more in the library
Cites 2
- Intravenous Ketamine for Late-Life Treatment-Resistant Depression: A Pilot Study of Tolerability, Safety, Clinical Benefits, and Effect on Cognition American Journal of Geriatric Psychiatry December 1, 2022
- Ninety-six hour ketamine infusion with co-administered clonidine for treatment-resistant depression: a pilot randomized controlled trial The World Journal of Biological Psychiatry February 26, 2016