JavaScript is disabled in your browser. You can still read and search, but features like search previews, menus, and forms may not work until it's enabled.

Efficacy and Safety of Esketamine Nasal Spray Plus an Oral Antidepressant in Elderly Patients With Treatment-Resistant Depression—TRANSFORM-3

July 27, 2020 DOI: 10.64239/pi-qt1701 (opens in new tab)

Relevant Not relevant

Study at a glance

AI-extracted from the abstract

Characteristics	Randomized controlled trial
Population	Patients 65 or older
Interventions	Nasal esketamine antidepressant
Topics	Depression Esketamine
Key findings	Nasal esketamine did not outperform placebo in patients 65 or older when initiated with a new antidepressant.

Abstract

Nasal esketamine did not outperform placebo in a randomized trial in patients 65 or older when initiated along with a new antidepressant.

Comparable studies

Other randomized controlled trials on esketamine for depression, most cited first.

Study	Year	Design	Participants
Efficacy and Safety of Flexibly Dosed Esketamine Nasal Spray Combined With a Newly Initiated Oral Antidepressant in Treatment-Resistant Depression: A Randomized Double-Blind Active-Controlled Study Adults with moderate to severe nonpsychotic depression and a history of nonresponse to...	2019	Phase 3, double-blind, active-controlled, multicenter randomized controlled trial	n = 227
Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression Adults with treatment-resistant depression who achieved stable remission or stable...	2019	Phase 3, multicenter, double-blind, randomized withdrawal study	n = 297
Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression Adults with DSM-IV-TR diagnosis of major depressive disorder and history of inadequate...	2017	Phase 2, double-blind, doubly randomized, delayed-start, placebo-controlled study	n = 67
Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study Depressed patients at imminent risk for suicide	2018	Randomized controlled trial	n = 68
Efficacy and Safety of Fixed-Dose Esketamine Nasal Spray Combined With a New Oral Antidepressant in Treatment-Resistant Depression: Results of a Randomized, Double-Blind, Active-Controlled Study (TRANSFORM-1) Adults with moderate-to-severe depression and nonresponse to at least two...	2019	Randomized controlled trial	n = 346

Explore topics

Depression Esketamine

By condition and practice

Esketamine for depression Ketamine for depression