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Ketamine and Esketamine: State of The Art – Interview

Samuel T. Wilkinson

April 21, 2026 DOI: 10.64239/pi-ec098 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Educational activity
Interventions Ketamine Esketamine
Topics Esketamine Ketamine
Key points Provides guidance on identifying appropriate candidates for ketamine or esketamine, strategies for maintenance and tapering, and management of acute side effects including dissociation, dysphoric reactions, nausea, and blood pressure changes.

Abstract

After completing this activity, participants should be able to: Identify appropriate candidates for ketamine or esketamine based on prior treatment failures, severity, substance use history, and relevant contraindications. Describe strategies for maintenance dosing, tapering, and managing rapid relapse after discontinuation of ketamine or esketamine. Apply clinic-based approaches to managing acute side effects, including dissociation, dysphoric reactions, nausea, and blood pressure changes.

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