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Real-world effectiveness and safety of intranasal esketamine for treatment-resistant depression: data from the enTRD registry

Maximilian Preiß, Valentin Popper, Luna Helene Charlotte Faber, Tg Baumgartner, Philip Miguel Baberis-Martinez, Edda Pjrek, Gregor Gryglewski, Lucie Bartova, Siegfried Kasper, Dan Rujescu, Lukas Pezawas

European Psychiatry June 23, 2026 DOI: 10.1192/j.eurpsy.2026.12234 (opens in new tab)

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Study at a glance

AI-extracted from the abstract

Characteristics	Observational Peer reviewed
Population	Patients with TRD from the enTRD registry
Topics	Depression Esketamine
Keywords	Nasal administration Action physics Onset of action Adverse effect Anesthesia Intensive care medicine
Key findings	Real-world data from the enTRD registry show effectiveness and safety of intranasal esketamine for TRD.

Abstract

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