miR-98-5p plays a critical role in depression and antidepressant effect of ketamine
Chao Huang, Yuanyuan Wang, Zifeng Wu, Jiali Xu, Ling Zhou, Di Wang, Ling Yang, Bin Zhu, Guiquan Chen, Cunming Liu, Chun Yang
Translational Psychiatry September 3, 2021 DOI: 10.1038/s41398-021-01588-0 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Animal study Peer reviewed |
|---|---|
| Population | Mice subjected to chronic social stress |
| Intervention | ketamine |
| Topics | Depression Esketamine Ketamine |
| Citations | 29 |
| Key points | miR-98-5p is downregulated in the prefrontal cortex and hippocampus of stressed mice, and ketamine's antidepressant effect requires upregulation of miR-98-5p. |
Abstract
Ketamine has been demonstrated to be a rapid-onset and long-lasting antidepressant, but its underlying molecular mechanisms remain unclear. Recent studies have emerged microRNAs as important modulators for depression treatment. In this study, we report that miR-98-5p is downregulated in the prefrontal cortex and hippocampus of mice subjected to chronic social stress, while overexpressing it by its agonist alleviates depression-like behaviors. More importantly, we demonstrate that miR-98-5p is upregulated by ketamine administration, while inhibition of it by its antagonist blocks the antidepressant effect of ketamine. Our data implicate a novel molecular mechanism underlying the antidepressant effect of ketamine, and that therapeutic strategies targeting miR-98-5p could exert beneficial effects for depression treatment.
Comparable studies
Other preclinical and animal studies on ketamine for depression, most cited first.
Citations in the library
Cited by 7
- Epigenetic mechanisms of rapid-acting antidepressants Translational Psychiatry September 4, 2024
- Novel mechanisms underlying rapid-acting antidepressants: ketamine-like compounds, neurosteroid GABAkines, and psychedelics. Drug Discovery Today June 1, 2025
- Epigenetic landscapes of classical psychedelics and ketamine: molecular mechanisms of long-lasting neuromodulation Molecular Psychiatry July 10, 2026
- MicroRNAs underlying the antidepressant effect of psilocybin – Establishing an nCounter pipeline for microRNA-quantification in the pig brain Research Square January 12, 2024
- Psilocybin-associated microRNA changes in the pig brain: Establishing an nCounter pipeline for cross-species microRNA quantification. European Journal of Pharmacology August 1, 2026
and 2 more in the library
Cites 8
- R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects Translational Psychiatry September 1, 2015
- Mechanistic Target of Rapamycin-Independent Antidepressant Effects of (R)-Ketamine in a Social Defeat Stress Model. Biological Psychiatry 2018
- Possible role of the gut microbiota–brain axis in the antidepressant effects of (R)-ketamine in a social defeat stress model Translational Psychiatry December 15, 2017
- Ketamine and depression: a narrative review Drug Design, Development and Therapy August 1, 2019
- Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites Translational Psychiatry November 7, 2019
and 3 more in the library