Functional connectivity between the amygdala and subgenual cingulate gyrus predicts the antidepressant effects of ketamine in patients with treatment‐resistant depression
Tomoyuki Nakamura, Masaru Tomita, N. Horikawa, M. Ishibashi, K. Uematsu, T. Hiraki, T. Abe, N. Uchimura
Neuropsychopharmacology Reports February 21, 2021 DOI: 10.1002/npr2.12165 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Observational cohort Peer reviewed |
|---|---|
| Population | Patients with treatment-resistant depression |
| Intervention | Ketamine |
| Topics | Depression Esketamine Ketamine |
| Citations | 29 |
| Key findings | Resting-state functional MRI may help predict treatment response to ketamine in treatment-resistant depression. |
Abstract
Approximately one‐third of patients with major depressive disorder develop treatment‐resistant depression. One‐third of patients with treatment‐resistant depression demonstrate resistance to ketamine, which is a novel antidepressant effective for this disorder. The objective of this study was to examine the utility of resting‐state functional magnetic resonance imaging for the prediction of treatment response to ketamine in treatment‐resistant depression.