Association of Combined Naltrexone and Ketamine With Depressive Symptoms in a Case series of Patients With Depression and Alcohol Use Disorder

Study at a glance

Characteristics	Randomized controlled trial Case report Peer reviewed
Interventions	Naltrexone Ketamine
Topics	Addiction Depression Esketamine Ketamine
Citations	152
Key findings	Naltrexone pretreatment does not diminish the antidepressant effects of ketamine.

This study examines whether naltrexone pretreatment interferes with the antidepressant effects of ketamine.

This study is part of the evidence base for a synthesis in the library. Here is how each one recorded it.

State of the evidence: Ketamine for addiction Supports

Naltrexone pretreatment did not diminish the antidepressant effects of ketamine.

Synthesized September 21, 2026

Other randomized controlled trials on ketamine for addiction, most cited first.

Study	Year	Design	Participants
Ketamine psychotherapy for heroin addiction: immediate effects and two-year follow-up. Detoxified heroin-addicted patients	2002	Randomized controlled trial	n = 70
A Single Ketamine Infusion Combined With Motivational Enhancement Therapy for Alcohol Use Disorder: A Randomized Midazolam-Controlled Pilot Trial. Adults with alcohol dependence engaged in motivational enhancement therapy	2019	Randomized controlled trial	n = 40
A Single Ketamine Infusion Combined With Mindfulness-Based Behavioral Modification to Treat Cocaine Dependence: A Randomized Clinical Trial. Cocaine-dependent adults	2019	Randomized controlled trial	n = 55
Single Versus Repeated Sessions of Ketamine-Assisted Psychotherapy for People with Heroin Dependence Detoxified inpatients with heroin dependence	2007	Randomized controlled trial	n = 59
Adjunctive Ketamine With Relapse Prevention–Based Psychological Therapy in the Treatment of Alcohol Use Disorder Patients with severe alcohol use disorder	2022	Randomized controlled trial	n = 96