Potential effect of ketamine in treatment for dextromethorphan use disorder exploding in Japanese young population.
Kaori Ishii, Kyoji Okita
Asian Journal of Psychiatry September 1, 2024 DOI: 10.1016/j.ajp.2024.104164 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Theoretical or philosophical paper Peer reviewed |
|---|---|
| Topics | Anxiety Depression Ketamine Esketamine |
| Keywords | Dextromethorphan Over-the-counter medication Self medication Trauma Mental-health depression Psychological disorders Substance-abuse addiction Drug misuse Self-medication Treatment-alternatives therapy options Clinical interventions Ketamine therapy Japan-healthcare japanese medicine Asian healthcare |
| Citations | 1 |
| Key points | Proposes that ketamine may be a useful alternative pharmacological treatment for patients with dextromethorphan use disorders who have severe trauma-related and mood symptoms. |
Abstract
In Japan, the landscape of clinical practice for substance use disorder is changing significantly, primarily due to an increase in patients using over-the-counter drugs. A major concern is the rising number of patients misusing dextromethorphan (DXM). These patients with DXM use disorders often have severe trauma-related and mood symptoms, and therefore try to cope with those symptoms by self-medicating with DXM. In this article, we propose that ketamine, which has similar psychopharmacological effects to DXM, may be a useful alternative pharmacological treatment for these patients.
Comparable studies
Other theoretical and historical papers on ketamine for anxiety, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Arketamine for cognitive impairment in psychiatric disorders | 2023 | Theoretical or philosophical paper | |
| Ketamine for Bipolar Depression: Biochemical, Psychotherapeutic, and Psychedelic Approaches | 2022 | Theoretical or philosophical paper |