Ketamine and Suicidal Ideation
May 14, 2019 DOI: 10.64239/pi-vl1406 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review |
|---|---|
| Intervention | Ketamine |
| Topics | Esketamine Ketamine |
| Key findings | Ketamine rapidly reduces suicidal ideation, but long-term data are needed before clinical use. |
Abstract
Several studies have shown that ketamine can lead to a rapid reduction in suicidal ideation. Ketamine’s rapid effect on suicidal ideation seems at least partially independent of its antidepressant effect. Given the lack of long-term follow-up, the concern for long-term exposure to ketamine, and the transient nature of the effect of a single-dose of ketamine, more long-term data are needed before ketamine can be used in clinical settings for the treatment of suicidal ideation.
Comparable studies
Other narrative reviews on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms | 2018 | Review | |
| Mechanisms of Ketamine Action as an Antidepressant | 2018 | Review | |
| Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation Adults with treatment-resistant depression | 2021 | Review | |
| Ketamine Pharmacology: An Update (Pharmacodynamics and Molecular Aspects, Recent Findings) | 2013 | Review | |
| A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders | 2017 | Review and consensus statement |