Beyond Enthusiasm: Ayahuasca and the Future of Depression Research.
Alberto Souza Sá Filho, James Oluwagbamigbe Fajemiroye, Antonio Egidio Nardi, Sérgio Machado
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) July 7, 2026 DOI: 10.47626/1516-4446-2026-5035 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Commentary Peer reviewed |
|---|---|
| Topics | Ayahuasca Depression |
| Key points | The author frames psychedelics as a potentially disruptive development in depression treatment, noting that many patients continue to experience partial response, relapse, or treatment resistance despite decades of prior work. The abstract is truncated and provides no specific results or conclusions. |
Abstract
Few topics in contemporary psychiatry generate as much fascination, hope, and discomfort as the therapeutic use of psychedelics.For some, they represent a long-awaited disruption in the treatment of depression, a field in which many patients still experience partial response, relapse, or treatment resistance despite decades of
In the evidence
This study is part of the evidence base for 2 syntheses in the library. Here is how each one recorded it.
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Argues that ayahuasca research for depression requires more rigorous methodology and caution before drawing conclusions about efficacy.
Synthesized
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State of the evidence: Ayahuasca Unclear
Argues that ayahuasca research for depression requires more rigorous methodology and caution before drawing conclusions about efficacy.
Synthesized