Toward Translatable Biomarkers of Psychedelic-Induced Neuroplasticity.
The American journal of psychiatry 2025 DOI: 10.1176/appi.ajp.20231054 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Review Peer reviewed |
|---|---|
| Topics | Ketamine Neuroplasticity |
| Keywords | Sv2a Psychoplastogen Psychedelics/hallucinogens/entheogens Neuroscience/brain-research/neurobiology Mental-health/psychiatry/psychological-treatment Neuroplasticity/brain-plasticity/neural-adaptation |
| Citations | 8 |
| Key findings | New advances in PET imaging could enable measurement of synaptic proteins in humans following psychedelic administration, providing a translatable biomarker of psychedelic-induced neuroplasticity. |
Abstract
Numerous preclinical studies have demonstrated that psychedelics promote the growth of cortical neurons in the prefrontal cortex. However, measuring psychedelic-induced structural plasticity in humans has remained a challenge. New advances in positron emission tomography imaging could facilitate the measurement of synaptic proteins in humans following psychedelic administration. Identifying a translatable biomarker of psychedelic-induced neuroplasticity would enable patient stratification and determination of optimal dosing paradigms while also facilitating the discovery of novel compounds that produce similar effects on structural neuroplasticity.