Efficacy of Electroconvulsive Therapy and Ketamine Therapy in Major Depressive Disorder; A Comparative Study
Asif Azeem Bajwa, Sohail Ali, Sikandar Ali Khan, Nida Saleem, Tashfeen Bin Nazir
Pakistan Armed Forces Medical Journal March 30, 2023 DOI: 10.51253/pafmj.v73i1.8818 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Comparative cross-sectional study Peer reviewed |
|---|---|
| Sample size | 40 |
| Population | Hospitalized patients with major depressive disorder |
| Interventions | Electroconvulsive therapy Ketamine infusions |
| Dose | low dose |
| Topics | Depression Ketamine Esketamine |
| Keywords | Electroconvulsive therapy Ect versus ketamine |
| Citations | 1 |
| Key findings | Low-dose ketamine has a more rapid impact than electroconvulsive therapy in improving symptoms of depression in major depressive disorder patients. |
Abstract
Objective: To evaluate and compare the efficacy of Electroconvulsive therapy (ECT) and Ketamine infusions in hospitalized patients suffering from major depressive disorder (MDD). Study
Design: Comparative cross-sectional study. Place and duration of study: Armed Forces Institute of Mental Health, Rawalpindi Pakistan, from Feb to Apr 2021. Methodology: Forty in-patients diagnosed as having MDD were randomly allocated ECT/Ketamine intervention as per international standards. Either group of patients acted as a control for the other. Their Beck Depressive Inventory (BDI) scores before and after the completion of treatment cycles were assessed to determine their response to treatment.
Results: The Ketamine-Group showed fewer depressive symptoms than the ECT Group. The depressive symptoms were reduced in 16(80.78%) patients after Ketamine infusions, while 15(77.78%) patients showed improvement after ECT sessions.In addition, the response to Ketamine was quicker.
Conclusion: This study has reported that low dose Ketamine has a more rapid impact than Electroconvulsive therapy in improving symptoms of depression in major depressive disorder patients.
Comparable studies
Other cross-sectional and survey studies on ketamine for depression, most cited first.
Citations in the library
Cites 7
- Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression JAMA Psychiatry December 27, 2017
- Ketamine for rapid reduction of suicidal thoughts in major depression: a midazolam-controlled randomized clinical trial American Journal of Psychiatry December 5, 2017
- ELEctroconvulsive therapy (ECT) vs. Ketamine in patients with Treatment-resistant Depression: The ELEKT-D study protocol. Contemporary Clinical Trials February 1, 2019
- Ketamine in electroconvulsive therapy for depressive disorder: A systematic review and meta-analysis. Journal of Psychiatric Research September 1, 2018
- A randomized, crossover comparison of ketamine and electroconvulsive therapy for treatment of major depressive episodes: a Canadian biomarker integration network in depression (CAN-BIND) study protocol BMC Psychiatry June 2, 2020
and 2 more in the library