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REDUCED PSYCHEDELIC EFFECTS OF KETAMINE INFUSION AFTER ELECTROCONVULSIVE THERAPY: A REPORT ON THREE CASES.

Emmanuel Kiiza Mwesiga, Alinaitwe Racheal, Janet Nakigudde, Seggane Musisi

preprint DOI: 10.31234/osf.io/9w5ub (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Case study Case report
Sample size 3
Population Patients receiving ketamine infusion for suicide ideations, two with prior ECT and one without
Intervention ketamine infusion
Topics Esketamine Ketamine Psychedelic-assisted therapy
Key findings Patients who received prior ECT had lower mean hallucinogen rating scale scores after ketamine infusion than the patient who did not.

Abstract

Psychedelic side effects of ketamine limit its use for the treatment of suicide ideations. Psychedelic effects after ketamine infusion were assessed in two patients received prior electroconvulsive therapy (ECT) and one who had not. Patients who received ECT prior to the infusion had lower mean scores on all domains of the hallucinogen rating scale compared to the patient who did not receive prior ECT. Confirming and understanding this association is needed through more rigorous research methods.

Comparable studies

Other case reports and case series on ketamine, most cited first.

Study Year Design Participants
The destruction of the lower urinary tract by ketamine abuse: a new syndrome? Young recreational abusers of street-ketamine in Hong Kong referred to urology units 2008 Retrospective case series n = 59
Electroconvulsive Therapy, Ketamine, and Esketamine in a Patient with Major Depressive Disorder and Multiple Comorbidities: A Case Report over 10-year Treatment from Adolescence to Adulthood. A patient with treatment-resistant depression and comorbid generalized anxiety... 2025 Case report n = 1
Treatment of compulsive behaviour in eating disorders with intermittent ketamine infusions Chronic and treatment-resistant eating disorder patients 1998 Case series n = 15
Oral Administration of the NMDA Receptor Antagonist S-Ketamine as Add-On Therapy of Depression: A Case Series Four depressed patients taking standard antidepressants 2009 Case series n = 4
A longitudinal case series of IM ketamine for patients with severe and enduring eating disorders and comorbid treatment‐resistant depression Patients with enduring eating disorders and treatment-resistant depression 2021 Case series n = 4

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Esketamine Ketamine Psychedelic-assisted therapy