Mania following ketamine abuse.
Yuan-Yuan Lu, Chieh-Hsin Lin, Hsien-Yuan Lane
Neuropsychiatric Disease and Treatment 2016 DOI: 10.2147/ndt.s97696 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Case study Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | 26-year-old man who abused ketamine by inhalation |
| Duration | 12 months of abuse |
| Topics | Ketamine Esketamine |
| Keywords | Antidepressant Bipolar Mania |
| Citations | 17 |
| Key findings | A possible relationship between manic symptoms and ketamine abuse is suggested by this case. |
Abstract
Ketamine, a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) receptor, has multiple clinical uses. On the other hand, ketamine abuse or recreational use has been gaining increasing attention. Induction of mania and psychotic symptoms has been reported in a patient receiving IV ketamine therapy for reflex sympathetic dystrophy. We here report a 26 year-old man who abused ketamine by inhalation for 12 months and developed manic-like symptoms after ketamine use. This case suggests a possible relationship between manic symptoms and ketamine abuse. To the best of our knowledge, this may be the first report regarding mania after recreational use of ketamine.
Comparable studies
Other case reports and case series on ketamine, most cited first.
Citations in the library
Cited by 3
- Affective Switch Associated With Oral, Low Dose Ketamine Treatment in a Patient With Treatment Resistant Bipolar I Depression. Case Report and Literature Review Frontiers in Psychiatry June 3, 2020
- The Role of Psychedelics in the Treatment of Substance Use Disorders: An Overview of Systematic Reviews. Brain Sciences September 28, 2025
- Ketamine and chronic treatment-resistant depression: real-world practice and after relapse. BMC Psychiatry October 28, 2024
Cites 8
- A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression Archives of General Psychiatry August 1, 2006
- mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists Science August 19, 2010
- Synaptic Dysfunction in Depression: Potential Therapeutic Targets Science October 4, 2012
- Rapid Resolution of Suicidal Ideation After a Single Infusion of anN-Methyl-D-Aspartate Antagonist in Patients With Treatment-Resistant Major Depressive Disorder The Journal of Clinical Psychiatry July 13, 2010
- From “Special K” to “Special M”: The Evolution of the Recreational Use of Ketamine and Methoxetamine CNS Neuroscience & Therapeutics June 1, 2013
and 3 more in the library