How ketamine helps to overcome depression

Thu N Huynh, Eric Klann

Study at a glance

Characteristics	Experimental study Peer reviewed
Population	Genetically modified mice
Intervention	Ketamine
Topics	Depression Esketamine Ketamine
Citations	1
Key findings	Ketamine reduces depression symptoms by targeting NMDA receptors in the brain.

Genetically modified mice shed new light on how ketamine can target NMDA receptors in the brain to reduce the symptoms of depression.

Other preclinical and animal studies on ketamine for depression, most cited first.

Study	Year	Design
Psychedelics, but Not Ketamine, Produce Persistent Antidepressant-like Effects in a Rodent Experimental System for the Study of Depression Rats	2020	Preclinical study
A Single Subanesthetic Dose of Ketamine Relieves Depression-like Behaviors Induced by Neuropathic Pain in Rats Rats with spared nerve injury (neuropathic pain model), sham-operated rats, and control...	2011	Animal experimental study
Comparison of (R)-ketamine and lanicemine on depression-like phenotype and abnormal composition of gut microbiota in a social defeat stress model Susceptible mice after chronic social defeat stress	2017	Preclinical animal study
Comparison of R-ketamine and rapastinel antidepressant effects in the social defeat stress model of depression Susceptible mice in the social defeat stress model	2016	Animal experimental study
Ketamine and its metabolite, (2R,6R)-HNK, restore hippocampal LTP and long-term spatial memory in the Wistar-Kyoto rat model of depression Wistar-Kyoto (WKY) rats and Wistar control rats	2020	Preclinical study