Ketamine for Adolescent Depression
February 28, 2023 DOI: 10.64239/pi-capst0804 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Randomized controlled trial Double-blind |
|---|---|
| Population | Adolescents with severe major depression |
| Intervention | Ketamine |
| Duration | 24 hours after infusion |
| Topics | Depression Esketamine Ketamine |
| Key findings | Ketamine had a strong effect size for reducing depressive symptoms 24 hours after infusion in adolescents with severe major depression. |
Abstract
Ketamine therapies can offer rapid relief of depression and an antisuicidal effect, making them of particular interest for adolescents with treatment-resistant depression. In 1 randomized, double-blind study of adolescents with severe major depression, ketamine had a strong effect size for reducing depressive symptoms 24 hours after infusion. Currently, there is minimal investigation and few studies on the use of ketamine in treatment-resistant adolescents with depression.