The Relationship Between Ketamine and Memory Impairment: A Systematic Review
Ghaith Al-Badran
Cumhuriyet Tıp Dergisi/Cumhuriyet Üniversitesi Tıp Fakültesi dergisi May 21, 2024 DOI: 10.7197/cmj.1452303 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review Peer reviewed |
|---|---|
| Sample size | 50 |
| Topics | Ketamine Esketamine |
| Keywords | Neurocognitive Cognition Association psychology Depression economics Clinical psychology Systematic review Psychological intervention Realm Cognitive psychology Medline Psychotherapist |
| Key findings | There is consistent evidence for a negative association between ketamine use and memory deterioration, though the relationship is complex and requires further study. |
Abstract
Various studies have reported conflicting results regarding the effect of ketamine on cognitive function, although increasing evidence supports its impact. This study aimed to investigate the potential correlation between Ketamine usage and memory deterioration, which is crucial for informing clinical practice and public health interventions. A systematic review was conducted, and six databases were scanned according to the PRISMA guidelines. As a result, 50 studies were analyzed to investigate the relationship between Ketamine and memory deterioration. It was found that most studies provided evidence for the claim that there is a negative association between Ketamine and cognitive function, specifically in the realm of memory. Some studies emphasized gender differences; however, their results were inconclusive. Studies have also found that the impact of ketamine is not limited to cognitive functions; it extends to other aspects such as depression, suicidal ideation, and neurocognitive functions. In conclusion, it is evident that there is an association between Ketamine and memory deterioration however, this relationship is challenging to develop and further studies are required.
Comparable studies
Other systematic reviews and meta-analyses on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| The effect of a single dose of intravenous ketamine on suicidal ideation: a systematic review and individual participant data meta-analysis Depressed patients with suicidal ideation at baseline | 2017 | Systematic review and individual participant data meta-analysis | n = 167 |
| Ketamine use: a review Ketamine users | 2011 | Systematic review | |
| Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression Participants with major depression in placebo-controlled, double-blind, randomized... | 2015 | Systematic review and meta-analysis | |
| Ketamine and postoperative pain – a quantitative systematic review of randomised trials Surgical patients from 25 countries | 2004 | Systematic review | n = 2,839 |
| Side-effects associated with ketamine use in depression: a systematic review. Patients with depression | 2018 | Systematic review |
Citations in the library
Cites 19
- Ketamine: a paradigm shift for depression research and treatment Neuron March 1, 2019
- Fast-acting antidepressant activity of ketamine: highlights on brain serotonin, glutamate, and GABA neurotransmission in preclinical studies. Pharmacology & Therapeutics July 1, 2019
- Repeated oral ketamine for out-patient treatment of resistant depression: randomised, double-blind, placebo-controlled, proof-of-concept study The British Journal of Psychiatry September 24, 2018
- Therapeutic Potentials of Ketamine and Esketamine in Obsessive–Compulsive Disorder (OCD), Substance Use Disorders (SUD) and Eating Disorders (ED): A Review of the Current Literature Brain Sciences June 27, 2021
- Ketamine augmentation of electroconvulsive therapy to improve neuropsychological and clinical outcomes in depression (Ketamine-ECT): a multicentre, double-blind, randomised, parallel-group, superiority trial The Lancet Psychiatry May 1, 2017
and 14 more in the library