The Relationship Between Ketamine and Memory Impairment: A Systematic Review
Cumhuriyet Tıp Dergisi/Cumhuriyet Üniversitesi Tıp Fakültesi dergisi May 21, 2024 DOI: 10.7197/cmj.1452303 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Systematic review Peer reviewed |
|---|---|
| Sample size | 50 |
| Topics | Ketamine Esketamine |
| Keywords | Neurocognitive Cognition Association psychology Depression economics Clinical psychology Systematic review Psychological intervention Realm Cognitive psychology Medline Psychotherapist |
| Key findings | There is consistent evidence for a negative association between ketamine use and memory deterioration, though the relationship is complex and requires further study. |
Abstract
Various studies have reported conflicting results regarding the effect of ketamine on cognitive function, although increasing evidence supports its impact. This study aimed to investigate the potential correlation between Ketamine usage and memory deterioration, which is crucial for informing clinical practice and public health interventions. A systematic review was conducted, and six databases were scanned according to the PRISMA guidelines. As a result, 50 studies were analyzed to investigate the relationship between Ketamine and memory deterioration. It was found that most studies provided evidence for the claim that there is a negative association between Ketamine and cognitive function, specifically in the realm of memory. Some studies emphasized gender differences; however, their results were inconclusive. Studies have also found that the impact of ketamine is not limited to cognitive functions; it extends to other aspects such as depression, suicidal ideation, and neurocognitive functions. In conclusion, it is evident that there is an association between Ketamine and memory deterioration however, this relationship is challenging to develop and further studies are required.