Ketamine Mechanism
September 30, 2019 DOI: 10.64239/pi-qt0702 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preprint |
|---|---|
| Topics | Esketamine Ketamine |
| Key points | Blocking opiate receptors with naltrexone prevented ketamine's antidepressant effect, indicating that the opioid system may mediate these effects. |
Abstract
Ketamine’s antidepressant effects, previously thought to involve the NMDA receptor, may be produced through the opioid system (because blocking opiate receptors with naltrexone blocked the antidepressant effect).