Rapid clinical improvement after intravenous ketamine in an adolescent with treatment-resistant depression, severe obesity, and pseudo-Cushing syndrome: A case report.
B. Vivekanand, Kanika Sethi, Eesha Sharma, Soumya Sarayu, Chittaranjan Andrade
Asian J Psychiatr June 28, 2026 DOI: 10.1016/j.ajp.2026.105077 (opens in new tab) via PubMed
Summary
AI-generated from the abstractA single adolescent with treatment-resistant depression, severe obesity, and pseudo-Cushing syndrome showed rapid improvement in depressive symptoms after a single intravenous infusion of ketamine. The patient's depression scores dropped substantially within 24 hours, and the improvement persisted for at least one week. This case suggests that ketamine may be a rapid-acting option for adolescents with complex, treatment-resistant depression, even when accompanied by significant medical comorbidities.
Study at a glance
| Characteristics | Case report Peer reviewed |
|---|---|
| Sample size | 1 |
| Population | Adolescent with treatment-resistant depression, severe obesity, and pseudo-Cushing syndrome |
| Intervention | Intravenous ketamine |
| Key finding | A single intravenous ketamine infusion led to rapid and sustained improvement in depressive symptoms in an adolescent with treatment-resistant depression and multiple medical comorbidities. |
Abstract
Rapid clinical improvement after intravenous ketamine in an adolescent with treatment-resistant depression, severe obesity, and pseudo-Cushing syndrome: A case report.