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What are the risks of serotonin syndrome when using MDMA and SSRIs together?

Zenodo (CERN European Organization for Nuclear Research) July 7, 2026 DOI: 10.5281/zenodo.21242234 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Review Peer reviewed
Topics MDMA Serotonin
Keywords Serotonin syndrome Drug Mirtazapine Health care Pharmacology Medline
Key findings Combined use of MDMA and SSRIs may increase the risk of serotonin syndrome.

Abstract

There is limited or indirect evidence suggesting that combined use of MDMA and SSRIs may increase the risk of serotonin syndrome. Healthcare providers should be vigilant in identifying symptoms and discourage such drug interactions.

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MDMA Serotonin