Psychedelic-Assisted Therapy for Anorexia Nervosa

Abstract

Anorexia Nervosa is a severe psychiatric disorder characterized by a distorted body image and an intense fear of weight gain, leading to self-imposed caloric restriction and excessive weight loss. Current treatments, including nutritional rehabilitation, psychotherapy, and pharmacological interventions, exhibit low long-term recovery rates. Psychedelic-assisted therapy (PAT) offers a promising avenue for treating anorexia by addressing the underlying psychological issues and comorbid disorders. Nine studies investigating the efficacy of psychedelic-assisted therapy in treating Anorexia Nervosa were systematically reviewed. The analysis indicates significant yet underexplored potential for PAT in the treatment of anorexia. The data overwhelmingly demonstrate a robust positive effect of the treatment across various psychedelic compounds. Common findings in the reviewed literature include a decrease in self-reported symptoms, weight gain, and a reduction in comorbidities. The reliance on self-reporting to measure clinical outcomes, small sample sizes, and the lack of blinding and placebo controls present significant challenges in interpreting the results and introduce the risk of biased reporting. The limited available data suggest that psychedelic-assisted therapy may be an effective treatment for eating disorders. However, caution is warranted in drawing definitive conclusions due to several significant limitations affecting data validity.