Undoing Addiction In The Brain's Reward Sector
Sophie Rovner
Chemical & Engineering News January 24, 2005 DOI: 10.1021/cen-v083n004.p009a (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Rodents (rats) |
| Intervention | Ibogaine |
| Topics | Addiction |
| Keywords | Citation Undoing Social media Icon Library science World wide web Psychoanalysis |
| Key findings | Ibogaine reduces ethanol consumption and limits relapse effects after alcohol withdrawal in rats. |
Abstract
New treatments for addiction could result from studies of ibogaine, an alkaloid derived from a West African shrub. Animal tests and anecdotal evidence in humans have indicated that ibogaine reduces cravings for alcohol and other drugs of abuse. Now, researchers at the University of California, San Francisco, have confirmed these findings in rodents and determined that ibogaine interacts with the brain's reward circuits. Ibogaine, which has hallucinogenic and neurotoxic side effects, has not been approved by the Food & Drug Administration. But some clinicians outside the U.S. use ibogaine to limit patients' withdrawal symptoms and craving for alcohol and other drugs, UCSF reports. Neuroscientists Dorit Ron and Patricia H. Janak and colleagues now provide evidence that backs the clinicians' faith in the compound [ J. Neurosci., 25, 619 (2005)]. The researchers confirmed previous findings that ibogaine reduces ethanol consumption in rats. They also showed that ibogaine limits relapse effects after alcohol withdrawal in rats. The ...
Comparable studies
Other preclinical and animal studies on addiction, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psychedelics reopen the social reward learning critical period Mice | 2023 | Experimental study in mice | |
| Glial Cell Line-Derived Neurotrophic Factor Mediates the Desirable Actions of the Anti-Addiction Drug Ibogaine against Alcohol Consumption Rats | 2005 | Experimental study | |
| Effects of ibogaine on acute signs of morphine withdrawal in rats: independence from tremor. Morphine-dependent rats | 1992 | Randomized controlled trial | |
| Structure-based discovery of conformationally selective inhibitors of the serotonin transporter. Mice | 2023 | Computational docking and experimental validation | |
| Reinforcing Effects of MDMA (‘Ecstasy’) in Drug-Naive and Cocaine-Trained Rats Rats | 2001 | Experimental study |