BIOLOGICAL ACTIVITY OF PSILOCYBIN EXTRACTS FROM THE FRUITING BODIES OF PSILOCYBE CUBENSIS ANTIOXIDANT AND ANTIMICROBIAL POTENTIAL
Shimal Yonuis Abdulhadi, Noor Alaubidi, Walla H. Shuker, Sanabel A. Abd Almajeed
Journal of Microbiology Biotechnology and Food Sciences March 13, 2025 DOI: 10.55251/jmbfs.12097 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Psilocybe cubensis mushrooms from Mosul forests |
| Topics | Psilocybin |
| Keywords | Antimicrobial Antioxidant Traditional medicine Pharmacology Hallucinogen Microbiology Biochemistry |
| Citations | 1 |
| Key findings | Psilocybin extracted from Psilocybe cubensis shows 40% antioxidant activity at 40 µg/ml and inhibits Escherichia coli with a 25.50 mm zone at 50 mg/ml. |
Abstract
Several fruiting bodies from Mosul forests were collected and were diagnosed using the Polymerase Chain Technique based on ITS region. It was proved they belong to Psilocybe cubensis mushroom, and was registered in the GenBank, NCBI in the serial number OR140556.1. The fruiting body powder was used in order to extract the alkaloid compound “Psilocybe”, which was analyzed using HPLC technique. As a result, a single peak for this compound appeared, at a retention time of 19.73 which is very close to the standard compound,s retention time of 19.98. Also, alkaloid compound “Psilocybe” showed the antioxidant activity by using DPPH test, and it was found out that “Psilocybe” exhibits antioxidant activity of 40% at a concentration of 40 µg/ml with a significant value compared to the standard antioxidant “Ascorbic acid”. In addition, the compound “Psilocybe” had activity against different types of pathogenic bacteria, and the highest diameter of the growth inhibitor towards Escherichia coli bacteria at a concentration of 50 mg/ml and reached 25.50 mm.
Comparable studies
Other experimental studies on psilocybin, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action Healthy human volunteers | 1998 | Experimental study | |
| Validation of the revised Mystical Experience Questionnaire in experimental sessions with psilocybin Participants in controlled laboratory experiments receiving a moderate to high oral... | 2015 | Validation study using pooled data from five laboratory experiments | n = 184 |
| Broadband Cortical Desynchronization Underlies the Human Psychedelic State Healthy human participants | 2013 | Experimental study | |
| Long-term follow-up of psilocybin-assisted psychotherapy for psychiatric and existential distress in patients with life-threatening cancer Participants with cancer-related psychiatric distress who completed a parent randomized... | 2020 | Long-term within-subjects follow-up analysis | n = 15 |
| Enzymatic Synthesis of Psilocybin | 2017 | Laboratory study |