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Catatonia Associated With First-Time Psilocybin Exposure: A Case Report

Jasbir Singh, Pranathi Mruthyunjaya

Cureus April 5, 2026 DOI: 10.7759/cureus.106474 (opens in new tab)

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Study at a glance

AI-extracted from the abstract
Characteristics Case report Peer reviewed
Sample size 1
Population A 28-year-old male patient
Intervention Psilocybin
Duration Six months
Topics Psilocybin
Citations 1
Key findings Psilocybin ingestion can induce catatonia in individuals without prior psychiatric or substance use history.

Abstract

In this case report, we highlight a 28-year-old male patient with predominantly retarded type of catatonia following a single incidence of psilocybin ingestion. This patient presented with a history of six months of mutism and inability to feed himself after consuming psilocybin for the first time. He did not have any history of psychiatric illness or substance use. Imaging and laboratory results were unremarkable. The goal of this case report is to document one of the earliest records of psilocybin-induced catatonia.

Comparable studies

Other case reports and case series on psilocybin, most cited first.

Study Year Design Participants
Psilocybin Mushroom (Psilocybe semilanceata) Intoxication with Myocardial Infarction 18-year-old man 1998 Case study n = 1
Relief from intractable phantom pain by combining psilocybin and mirror visual-feedback (MVF) Person with leg amputation and phantom-limb pain 2018 Case study n = 1
Hallucinogen persisting perception disorder after psilocybin consumption: a case study 18-year-old man with HPPD after mixed psilocybin and cannabis intoxication 2005 Case study n = 1
Microdosing psilocybin for chronic pain: a case series Individuals with chronic neuropathic pain 2022 Case series n = 3
Psilocybin and Obsessive Compulsive Disorder Individual with Obsessive Compulsive Disorder 2014 Case study n = 1

Citations in the library

Cites 3

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Psilocybin