Dynamic reconfiguration of the default mode network during narrative comprehension
Erez Simony, Christopher J Honey, Janice Chen, Olga Lositsky, Yaara Yeshurun, Ami Wiesel, Uri Hasson
Nature Communications July 18, 2016 DOI: 10.1038/ncomms12141 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Experimental study Peer reviewed |
|---|---|
| Population | Human subjects |
| Topics | Default mode network |
| Citations | 689 |
| Key findings | ISFC reveals that the default mode network reconfigures to encode stimulus-dependent information, and its coupling strength predicts memory of narrative segments. |
Abstract
Does the default mode network (DMN) reconfigure to encode information about the changing environment? This question has proven difficult, because patterns of functional connectivity reflect a mixture of stimulus-induced neural processes, intrinsic neural processes and non-neuronal noise. Here we introduce inter-subject functional correlation (ISFC), which isolates stimulus-dependent inter-regional correlations between brains exposed to the same stimulus. During fMRI, we had subjects listen to a real-life auditory narrative and to temporally scrambled versions of the narrative. We used ISFC to isolate correlation patterns within the DMN that were locked to the processing of each narrative segment and specific to its meaning within the narrative context. The momentary configurations of DMN ISFC were highly replicable across groups. Moreover, DMN coupling strength predicted memory of narrative segments. Thus, ISFC opens new avenues for linking brain network dynamics to stimulus features and behaviour.
Comparable studies
Other experimental studies on default mode network, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Functional connectivity of default mode network components: Correlation, anticorrelation, and causality Healthy subjects | 2008 | Observational study using resting-state fMRI and seed correlation analysis | |
| Patterns of Brain Activity Supporting Autobiographical Memory, Prospection, and Theory of Mind, and Their Relationship to the Default Mode Network Healthy subjects | 2009 | Experimental study using fMRI | |
| Broadband Cortical Desynchronization Underlies the Human Psychedelic State Healthy human participants | 2013 | Experimental study | |
| The brain on art: intense aesthetic experience activates the default mode network Human observers | 2012 | Observational study with fMRI and behavioral analysis | |
| Default mode network can support the level of detail in experience during active task states Human participants performing working-memory tasks in an fMRI scanner | 2018 | Experimental study with fMRI and self-report |
Citations in the library
Cited by 28
- The default mode network in cognition: a topographical perspective Nature Reviews Neuroscience July 5, 2021
- The default mode network: where the idiosyncratic self meets the shared social world Nature Reviews Neuroscience January 22, 2021
- The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow Nature Neuroscience January 28, 2025
- Ongoing Brain Activity and Its Role in Cognition: Dual versus Baseline Models The Neuroscientist May 25, 2022
- As without, so within: how the brain's temporo-spatial alignment to the environment shapes consciousness Interface Focus April 14, 2023
and 23 more in the library
Cites 5
- The Brain's Default Mode Network Annual Review of Neuroscience May 4, 2015
- On the relationship between the “default mode network” and the “social brain” Frontiers in Human Neuroscience 2012
- Effects of model-based physiological noise correction on default mode network anti-correlations and correlations Neuroimage May 15, 2009
- A common neural code for similar conscious experiences in different individuals Proceedings of the National Academy of Sciences September 15, 2014
- Task-positive Functional Connectivity of the Default Mode Network Transcends Task Domain Journal of Cognitive Neuroscience December 1, 2015