Ketamine
Rainer Kohrs, Marcel E. Durieux
Anesthesia & Analgesia November 1, 1998 DOI: 10.1097/00000539-199811000-00039 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Peer reviewed |
|---|---|
| Intervention | Ketamine |
| Topics | Ketamine Esketamine |
| Keywords | Anesthesia |
| Citations | 610 |
| Key points | The text states that ketamine was introduced over 30 years ago as a hoped-for "monoanesthetic" providing analgesia, amnesia, loss of consciousness, and immobility, but that this expectation was not fulfilled because significant side effects were reported, after which its role diminished rapidly with the arrival of other intravenous anesthetics. |
Abstract
Ketamine has a special position among anesthetic drugs. It was introduced into clinical practice >30 yr ago with the hope that it would function as a "monoanesthetic" drug: inducing analgesia, amnesia, loss of consciousness, and immobility. This dream was not fulfilled because significant side effects were soon reported. With the introduction of other IV anesthetic drugs, ketamine's role diminished rapidly.
Citations in the library
Cited by 55
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- Mechanisms of Ketamine Action as an Antidepressant Molecular Psychiatry March 13, 2018
- Ketamine Pharmacology: An Update (Pharmacodynamics and Molecular Aspects, Recent Findings) CNS Neuroscience & Therapeutics April 10, 2013
- R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects Translational Psychiatry September 1, 2015
- Ketamine and postoperative pain – a quantitative systematic review of randomised trials Pain December 15, 2004
and 50 more in the library
Cites 5
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