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Efficacy and safety of esketamine for pain control after cesarean delivery: a systematic review and meta-analysis of randomized controlled trials

Tiejia Jiang, Rui Zhao

Frontiers in Pharmacology December 1, 2025 DOI: 10.3389/fphar.2025.1708221 (opens in new tab)

Study at a glance

AI-extracted from the abstract
Characteristics Randomized controlled trial Peer reviewed
Population Pregnant women in China
Intervention Esketamine
Topics Ketamine Esketamine
Keywords Randomized controlled trial Anesthesia Pain control Adverse effect Pregnancy Clinical trial Medline
Key findings Esketamine shows favorable efficacy for postoperative analgesia and is associated with a lower risk of postpartum depression, but the result is unstable and may increase dizziness in pregnant women over 30.

Abstract

As a therapy for postoperative analgesia, esketamine shows relatively favorable efficacy in pain control and is associated with a lower risk of postpartum depression. However, this result is unstable. Furthermore, esketamine may increase the risk of dizziness in pregnant women aged over 30 years. Since all the experiments in this study are conducted in China, there are certain regional limitations.

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