A clinical protocol for group-based ketamine-assisted therapy in a community of practice: the Roots To Thrive model
Shannon Dames, Pamela Kryskow, Vivian W. L. Tsang, Elena Argento
Frontiers in Psychiatry September 22, 2025 DOI: 10.3389/fpsyt.2025.1568017 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Longitudinal follow-up study Peer reviewed |
|---|---|
| Topics | Esketamine Ketamine |
| Keywords | Protocol science Indigenous Medline Clinical trial Patient safety Intervention counseling Intensive care medicine Medical emergency Nursing |
| Citations | 3 |
| Key findings | RTT-KaT offers a structured, scalable, evidence-informed, and culturally responsive model that bridges clinical safety with both Western and Indigenous knowledge systems. |
Abstract
RTT-KaT offers a structured, scalable, evidence-informed, and culturally responsive model that bridges clinical safety with both Western and Indigenous knowledge systems. A longitudinal follow-up study is currently underway to evaluate long-term impact and guide future implementations.
Comparable studies
Other observational and cohort studies on ketamine, most cited first.
| Study | Year | Design | Participants |
|---|---|---|---|
| Taming the Ketamine Tiger Volunteers from a prison population | 2010 | Observational study | n = 20 |
| Increased spontaneous MEG signal diversity for psychoactive doses of ketamine, LSD and psilocybin Humans | 2017 | Observational study | |
| Disruption of Frontal–Parietal Communication by Ketamine, Propofol, and Sevoflurane Surgical patients undergoing induction of anesthesia with intravenous ketamine | 2013 | Observational cohort | n = 30 |
| Do the dissociative side effects of ketamine mediate its antidepressant effects? Treatment-resistant inpatients with major depressive disorder or bipolar disorder | 2014 | Observational cohort | n = 108 |
| Concomitant BDNF and sleep slow wave changes indicate ketamine-induced plasticity in major depressive disorder Patients with treatment-resistant major depressive disorder | 2012 | Observational cohort | n = 30 |
Citations in the library
Cited by 3
- Intercultural pathways to indigenous mental health: the integration of ayahuasca in community care in the Yaqui intercultural medicine clinic in Sonora, Mexico Frontiers in Public Health October 9, 2026
- Policy pathways and historical insights: Canada's evolving approach to psychedelic access for end-of-life distress International Journal of Drug Policy July 6, 2026
- Improving access to psilocybin-assisted therapy: barriers, challenges, and recommendations Frontiers in Public Health January 29, 2026
Cites 12
- The entropic brain: a theory of conscious states informed by neuroimaging research with psychedelic drugs Frontiers in Human Neuroscience 2014
- A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders JAMA Psychiatry March 1, 2017
- Ketamine: a paradigm shift for depression research and treatment Neuron March 1, 2019
- Ketamine: 50 Years of Modulating the Mind Frontiers in Human Neuroscience November 29, 2016
- The hidden therapist: evidence for a central role of music in psychedelic therapy Psychopharmacology February 1, 2018
and 7 more in the library