A real-world pharmacovigilance study of adverse events associated with esketamine: disproportionality analysis and detection of potential drug-drug interaction signals
Claudia Pisanu, Shungo Imai, Masami Tsuchiya, Mika Inoue, Keisuke Ikegami, Gianpaolo Zammarchi, Hayato Kizaki, Satoko Hori
European Journal of Clinical Pharmacology December 22, 2025 DOI: 10.1007/s00228-025-03954-z (opens in new tab)
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Study at a glance
AI-extracted from the abstract| Characteristics | Observational study Peer reviewed |
|---|---|
| Intervention | Esketamine |
| Topics | Esketamine |
| Keywords | Pharmacovigilance Adverse effect Intensive care medicine Pharmacology Drug interaction Risk assessment Medline |
| Citations | 3 |
| Key findings | Esketamine is associated with potential adverse effects and drug-drug interaction signals in a real-world setting. |
Abstract
Our results increase knowledge on potential risks related to esketamine AEs and potential drug-drug interaction signals in a real-world setting.
Comparable studies
Other observational and cohort studies on esketamine, most cited first.
Citations in the library
Cited by 2
- Comparative network pharmacology analysis of ketamine and xanomeline in major depressive disorder: Shared and distinct molecular mechanisms. Progress in Neuro-Psychopharmacology and Biological Psychiatry June 20, 2026
- Pleiotropic modulation of the gut-brain-lung axis by ketamine and its enantiomers. Molecular Psychiatry April 13, 2026
Cites 8
- Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation American Journal of Psychiatry March 17, 2021
- Ketamine: A tale of two enantiomers Journal of Psychopharmacology November 6, 2020
- Long-Term Safety and Maintenance of Response With Esketamine Nasal Spray in Participants With Treatment-Resistant Depression: Interim Results of the SUSTAIN-3 Study Neuropsychopharmacology May 12, 2023
- Pharmacodynamic Interactions Between Ketamine and Psychiatric Medications Used in the Treatment of Depression: A Systematic Review The International Journal of Neuropsychopharmacology June 25, 2021
- A replication study using the World Health Organization pharmacovigilance database (VigiBase®) to evaluate whether an association between ketamine and esketamine and alcohol and substance misuse exists. Journal of Affective Disorders October 15, 2024
and 3 more in the library