Gender Differences in Suicidal and Self-Harming Responses to Esketamine: A Real-World Retrospective Study
Vassilis Martiadis, Fabiola Raffone, Danilo Atripaldi, Serena Testa, Paolo Giunnelli, Rita Cerlino, Manlio Russo, Azzurra Martini, Enrico Pessina, Carlo Ignazio Cattaneo, Domenico de Berardis
Current Neuropharmacology October 20, 2025 DOI: 10.2174/011570159x392347250929114024 (opens in new tab)
Study at a glance
AI-extracted from the abstract| Characteristics | Preliminary study Peer reviewed |
|---|---|
| Population | People with treatment-resistant depression |
| Intervention | Esketamine |
| Topics | Esketamine |
| Citations | 21 |
| Key points | Esketamine rapidly improved suicidality and depression in treatment-resistant depression, with preliminary evidence of gender-specific responses. |
Abstract
Esketamine rapidly improved suicidality and depression in TRD, with preliminary evidence suggesting gender-specific responses, and highlighting the importance of tailored interventions to maximize outcomes. Further research is needed to confirm these differences, explore the long-term effects, and understand the underlying mechanisms.
Citations in the library
Cited by 15
- Integrating Psychiatric, Psychotherapeutic, and Nursing Care in Intranasal Esketamine for Treatment-Resistant Depression Journal of Clinical Medicine February 20, 2026
- Personalizing esketamine treatment in TRD and TRBD: the role of mentalization, cognitive rigidity, psychache, and suicidality. Frontiers in Psychiatry 2025
- Esketamine in treatment-resistant depression with and without comorbid borderline personality disorder: A real-world longitudinal study of suicidal ideation and self-harm. Asian Journal of Psychiatry June 1, 2026
- Systematic review and meta-analysis of intranasal esketamine for treatment-resistant depression: Evidence from real-world studies. Journal of Affective Disorders January 28, 2026
- Ketamine as a potential cognitive enhancer in neurological disorders: evidence from preclinical and clinical studies Frontiers in Neurology March 30, 2026
and 10 more in the library