Skip to content

Psilocybin as a Serotonergic Therapy in Epilepsy: Narrative Review of Therapeutic Potentials and Seizure Risks

Miguel Benjamín Cervera-Sánchez, Daniel San-Juan, Roberto Díaz-peregrino, Evelin Zulema Camacho-Castillo, Sthefany Anahi Bringas-Ortiz, Christian Padilla-Cabezutd

December 29, 2025 DOI: 10.22541/au.176701186.65064859/v1 (opens in new tab)

Relevant Not relevant

Study at a glance

AI-extracted from the abstract
Characteristics Narrative review
Topics Psilocybin Serotonin
Keywords Narrative review Psychotherapist Epilepsy Hallucinogen Review article Medline Obsessive compulsive
Key findings Psilocybin presents a paradoxical relationship with seizures and epilepsy, indicating both potential therapeutic effects and risks that are not yet fully understood.

Abstract

Background: Psilocybin has shown promise in neuropsychiatric disorders but presents a paradoxical relationship with seizures and epilepsy.

Methods: A narrative review was conducted up to November 23, 2025. We conducted structured literature searches a

Comparable studies

Other narrative reviews on serotonin, most cited first.

Study Year Design Participants
Serotonin research: contributions to understanding psychoses 2008 Review
Human psychopharmacology of Ecstasy (MDMA): a review of 15 years of empirical research 2001 Review
Hallucinogens and Serotonin 5-HT2A Receptor-Mediated Signaling Pathways 2017 Review
3,4‐Methylenedioxymethamphetamine (MDMA, “Ecstasy”): pharmacology and toxicology in animals and humans 1994 Review
(±)3,4-Methylenedioxymethamphetamine (‘Ecstasy’)-Induced Serotonin Neurotoxicity: Studies in Animals 2000 Review

Related reading

Explore topics

Psilocybin Serotonin